Congenital Ichthyosis 1 and 2 in Golden Retrievers
Congenital ichthyosis is a skin condition in which the outer layer of the skin does not form properly and results in scaling. The condition often progresses to large patches of thickened, black, scaly skin. Two genetic variants have been associated with congenital ichthyosis in the Golden Retriever.
Congenital Myasthenic Syndrome (CMS) in Golden Retrievers
Congenital myasthenic syndrome is a group of inherited neuromuscular disorders that are characterized by progressive muscle weakening that worsens with exercise.
Degenerative Myelopathy (DM)
Degenerative myelopathy (DM) is an inherited neurologic disorder of dogs characterized by gradual muscle wasting and loss of coordination typically beginning in the hind limbs.
Neuronal Ceroid Lipofuscinosis (NCL) in Golden Retrievers
Neuronal ceroid lipofuscinosis results from the accumulation of granules in the neurons of the brain and spinal cord. This progressive neurological disorder manifests as behavioral changes coupled with a loss of coordination and blindness.
Progressive Retinal Atrophy (PRA1 and PRA2) in Golden Retrievers
Progressive retinal atrophy (PRA) is characterized by bilateral degeneration of the retina resulting in progressive vision loss leading to total blindness. More than one form of PRA affects Golden Retrievers, and causal mutations in three distinct genes have been identified; two of those mutations lead to PRA1 and PRA2.
Progressive Rod-Cone Degeneration (PRA-prcd)
Progressive rod-cone degeneration (PRCD) is an inherited form of late-onset progressive retinal atrophy (PRA) that has been identified in many dog breeds.
Sensory Ataxic Neuropathy (SAN) in Golden Retrievers
Sensory ataxic neuropathy is a progressive neurological disorder characterized by involuntary muscle movements and abnormal posture resulting from degeneration of the nerves controlling muscle movement. It affects both sexes but is only inherited maternally.